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approximately equal numbers of patients were randomized to receive initial therapy with 100 mg of januvia in combination with 30 mg of pioglitazone once daily or 30 mg of pioglitazone once daily as monotherapy.

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when januvia was coadministered with a sulfonylurea or with insulin, the percentage of patients with at least one adverse reaction of hypoglycemia was higher than in the corresponding placebo group table 3 .

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in the study of januvia as add-on combination therapy with metformin and rosiglitazone table 1 , through week 54 the adverse reactions reported regardless of investigator assessment of causality in 5 of patients treated with januvia and more commonly than in patients treated with placebo were upper respiratory tract infection januvia, 15.


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